This article supersedes TSB 25-2322 to update the Service Procedure, Labor Operations and Parts List. Some of the vehicles listed in the Model statement above may exhibit an upper engine ticking or tapping noise at idle. Customers may also report experiencing rough engine performance, engine misfire, or a malfunction indicator lamp (MIL) with diagnostic trouble code (DTC) P0301-P0308 in the powertrain control module (PCM). This may be due to camshaft and/or valve tappet having excess wear within the engine assembly.
full bulletin at NHTSA ↗2021 Ford E-450 engine problems
moderate 4 complaints filed with NHTSA · avg repair $3,100 · see engine across all vehicles →
Complaints
4
Recalls
0
Avg fix
$3,100
Is there a fix? Manufacturer service bulletins
The manufacturer has issued service bulletins covering engine on this vehicle — documented repair instructions, service campaigns, or warranty extensions sent to dealers. A TSB isn't a recall (it's not a free safety remedy), but it's the manufacturer acknowledging the issue and how to fix it.
Some 2021-2025 Expedition/Navigator/F-150/F-Super Duty/F-53 Motorhome/F59 Commercial Stripped Chassis/F-650/F-750/Transit vehicles equipped with a 2.7L/3.5L (non hybrid)/6.8L/7.3L engine and 2021-2026 E-Series may exhibit a rattle/scraping noise from the bellhousing area on start-up. Workshop Manual (WSM), Section 303-00 Engine System - General Information > Diagnosis and Testing and 303-06 > Starting System has been updated to address this condition. Additionally, WSM, Section 303-01 > Removal and Installation > Engine to Transmission Spacer Plate has been added to address this condition. Refer to the revised WSM sections for normal diagnosis.
full bulletin at NHTSA ↗Some 2021-2024 Edge/Nautilus, 2021-2025 Bronco/Bronco Sport/E-Series/Escape/Corsair/Expedition/Navigator/Explorer/Aviator/F-150/F-Super Duty/Mustang/Ranger, and 2022-2025 Maverick vehicles may require an A/C compressor clutch assembly replacement be performed for various concerns. Workshop Manual (WSM), Section 412-00 Removal and Installation has been updated to eliminate the need to remove and install the A/C compressor to change out the A/C Compressor clutch assembly.
full bulletin at NHTSA ↗Some of the vehicles listed in the Model statement above may exhibit an upper engine ticking or tapping noise at idle. Customers may also report experiencing rough engine performance, engine misfire, or a malfunction indicator lamp (MIL) with diagnostic trouble code (DTC) P0301-P0308 in the powertrain control module (PCM). This may be due to camshaft and/or valve tappet having excess wear within the engine assembly.
full bulletin at NHTSA ↗Some 2020 Continental, 2020-2024 Edge/Nautilus, 2020-2025 Explorer/Aviator/Escape/Corsair/F-150/F-Super Duty/Ranger/Transit/E-Series, 2021-2025 Bronco, and 2022-2025 Maverick vehicles may require an engine cooling system flush to be performed for various concerns. Workshop Manual (WSM), Section 303-03 has been updated to eliminate the need to remove and install the radiator assembly to perform a radiator flush.
full bulletin at NHTSA ↗Source: NHTSA manufacturer communications. Bring the bulletin number to your dealer or shop.
What owners are reporting 1 most recent
Engine camshaft and lifters failed. Truck is at a Ford dealer. Engine could fail in the middle of the road, causing an accident. This is our eighth vehicle with the same issue taken to a ford dealer in the past year. A little knocking noise started that quickly turned into a loud knocking/rattling noise. No lights came on the truck.
Had engine trouble with your 2021 Ford E-450?
File a complaint with NHTSA → It's free, official, and how every report above got here — owner filings are the federal safety record this page is built on.
Common questions
How serious is the engine problem on the 2021 Ford E-450?
It's a documented issue but not catastrophic. 4 complaints have been filed. Repairs average $3,100 and most owners catch it before it causes a breakdown.
At what mileage does the engine typically fail?
Mileage data is limited for this issue. Owners report failures across a wide range, suggesting cause is more about driving conditions and maintenance than mileage alone.
What does it cost to fix?
Independent shops typically charge around $3,100 for engine repairs on this vehicle. Dealer pricing tends to run 20-40% higher. The exact figure depends on the specific failure mode, parts availability, and your local labor rates. If you're outside factory warranty, an extended service contract often covers this category.
Are there any recalls related to engine?
No active recalls currently cover engine issues on this vehicle. The complaints filed represent owner-reported failures that haven't risen to the level of a manufacturer-issued recall — but they're still worth knowing about before you buy or budget for repairs.
Related
Complaint and recall data sourced from the National Highway Traffic Safety Administration (NHTSA)
public records database. Verify the raw federal record at
nhtsa.gov/vehicle/2021/Ford/E-450.
Severity ratings are derived from reported crashes, fires, injuries, and fatalities. Repair cost estimates are
independent-shop national averages and may differ in your area. Some links on this page are affiliate links.