Engine keeps having a misfire that Mercedes put a TSB out for and once the misfire happen I cause the vehicle to go in a limp mode which causes the vehicle to loose power happened to me in the freeway. The car had 54K miles and Mercedes refused to repair the issue as the engine part failure isn’t common.
2021 Mercedes-Benz E-Class engine problems
moderate Owners of the 2021 Mercedes-Benz E-Class have filed 3 NHTSA complaints about the engine at roughly $3,100 to repair (U.S. federal records, as of July 2026). Source: NHTSA Office of Defects Investigation. See engine across all vehicles →
Complaints
3
Recalls
0
Avg fix
$3,100
| Model year | engine complaints |
|---|---|
| 2017 E-Class | 31 |
| 2018 E-Class | 7 |
| 2019 E-Class | 6 |
| 2020 E-Class | 3 |
| 2021 E-Class (this page) | 3 |
| 2023 E-Class | 5 |
What owners are reporting 3 most recent
The 48 volt battery on this mild hybrid vehicle failed and the car was unable to be started on May 3, 2021, with 196 miles on the odometer, a mere 15 days after delivery. It had to be taken by flatbed to the dealer where ultimately the 48 volt battery was replaced. Then again on June 5, 2021, the car was again unable to be started, with a mere 735 miles on the odometer. Again, the car had to…
My 2021 Mercedes-Benz E350 (VIN [XXX] ) developed a serious engine issue involving cylinder misfire and check engine light. The dealer diagnosed it as a leaking exhaust valve on cylinder 4, related to TSB LI01.30-P-072328, which documents valve seat wear in M260 engines. This is a known defect acknowledged by Mercedes in technical bulletins, and other customers in the U.S. have received warranty…
Had engine trouble with your 2021 Mercedes-Benz E-Class?
File a complaint with NHTSA → It's free, official, and how every report above got here — owner filings are the federal safety record this page is built on.
Common questions
How serious is the engine problem on the 2021 Mercedes-Benz E-Class?
It's a documented issue but not catastrophic. 3 complaints have been filed. Repairs average $3,100 and most owners catch it before it causes a breakdown.
At what mileage does the engine typically fail?
Mileage data is limited for this issue. Owners report failures across a wide range, suggesting cause is more about driving conditions and maintenance than mileage alone.
What does it cost to fix?
Independent shops typically charge around $3,100 for engine repairs on this vehicle. Dealer pricing tends to run 20-40% higher. The exact figure depends on the specific failure mode, parts availability, and your local labor rates. If you're outside factory warranty, an extended service contract often covers this category.
Are there any recalls related to engine?
No active recalls currently cover engine issues on this vehicle. The complaints filed represent owner-reported failures that haven't risen to the level of a manufacturer-issued recall — but they're still worth knowing about before you buy or budget for repairs.
Related
Complaint and recall data sourced from the National Highway Traffic Safety Administration (NHTSA)
public records database. Verify the raw federal record at
nhtsa.gov/vehicle/2021/Mercedes-Benz/E-Class.
Severity ratings are derived from reported crashes, fires, injuries, and fatalities. Repair cost estimates are
independent-shop national averages and may differ in your area. Some links on this page are affiliate links.