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P0300 — Random / multiple cylinder misfire detected.

Code P0300 is a standard OBD-II diagnostic trouble code: Random / multiple cylinder misfire detected.

In ProblemsByVin's analysis of the NHTSA owner-complaint record, owners cite P0300 across 310 vehicle failure patterns. Diagnostic codes in complaints are reported by owners and are unverified — they point to where this code shows up, not a confirmed diagnosis. Open a page below for the full pattern (symptoms, mileage, repair costs owners cite).

Vehicles where owners report P0300 310 patterns · top 60

2024 Cadillac Escalade
engine — Catastrophic Engine Failure / Complete Shutdown
2024 Chevrolet Trax
electrical — Engine Oil Pressure Faults and Hesitation
2023 Chevrolet Silverado
engine — Bearing/Crankshaft Failure and Engine Seizure
2023 Chevrolet Suburban
engine — Lifter failure / AFM/DFM lifter collapse
2023 Chevrolet Tahoe
electrical — Engine Power Loss / Reduced Power / Stalling
2023 GMC Yukon XL
engine — Catastrophic engine seizure with loss of power at highway speeds
2022 Chevrolet Equinox
engine — Charge Air Cooler Moisture Accumulation / Air Induction System Failure
2022 Ford Explorer
electrical — Check Engine Light with random misfire code P0300
2022 GMC Sierra
engine — Sudden engine seizure at highway speed
2022 Honda Accord
engine — Cylinder Head Crack / Porosity
2022 Honda CR-V
electrical — Engine limp mode and acceleration loss
2022 Hyundai Palisade
engine — Excessive oil consumption / burning
2022 Hyundai Santa Fe
engine — Cylinder misfire — intermittent
2022 Volkswagen Tiguan
electrical — Delayed or erratic acceleration and engine stalling
2022 Volkswagen Taos
cruise control — Accelerator Unresponsiveness / Delayed Throttle Response
2021 Chevrolet Suburban
engine — Lifter Collapse / Failure
2021 Chevrolet Silverado
engine — Lifter failure / collapse
2021 Chevrolet Tahoe
powertrain — Engine Catastrophic Failure – Internal Mechanical Breakdown
2021 Chevrolet Silverado
electrical — Engine Power Loss / Limp Mode
2021 Chevrolet Tahoe
engine — Valve Lifter Failure
2021 Chevrolet Tahoe
electrical — Fuel Pump Power Control Module Failure
2021 Ford F-150
engine — Engine misfire and ignition/compression issues
2021 GMC Sierra
engine — 6.2L gasoline engine bearing/rod failure and catastrophic seizure
2021 GMC Yukon XL
engine — Connecting Rod or Internal Rod Bearing Failure
2021 Honda CR-V
engine — Head gasket failure with coolant intrusion
2021 Honda Ridgeline
engine — Cold-weather limp mode after extended highway driving
2021 Honda Accord
powertrain — Head gasket failure
2021 Hyundai Tucson
engine — Engine Stalling / Sudden Power Loss (Limp Mode)
2021 Jeep Gladiator
engine — Camshaft Failure and Valve Train Damage
2021 Kia Seltos
powertrain — Engine misfire and cylinder damage
2021 Kia Forte
engine — Sudden engine loss of power and stalling at highway speeds
2020 Chevrolet Silverado
engine — Lifter and camshaft failure
2020 Chevrolet Silverado
powertrain — Engine misfire, lifter failure, and catastrophic engine damage
2020 Ford Escape
fuel system — Fuel-injector failure
2020 Ford Mustang
engine — Coolant intrusion into cylinders and head gasket failure
2020 GMC Yukon XL
engine — Lifter Failure with Camshaft Damage
2020 Honda Accord
engine — Head gasket failure
2020 Honda Pilot
engine — Connecting Rod/Bearing Failure
2020 Jeep Gladiator
engine — Cylinder Misfire (P0300, P0301, P0305)
2020 Kia Telluride
powertrain — Excessive Oil Consumption / Piston Ring Failure
2020 Kia Telluride
engine — Excessive oil consumption
2020 Toyota Highlander
electrical — Engine control unit (ECU) failure
2019 Acura RDX
engine — Sudden Power Loss / Limp Mode During Acceleration
2019 Chevrolet Tahoe
powertrain — Fuel pump failure — stalling and loss of power
2019 Chevrolet Trax
engine — Evaporative emission system (purge valve) failures
2019 Ford Fusion
engine — Coolant intrusion into cylinders (head gasket/block defect)
2019 Ford Escape
engine — Coolant Intrusion into Cylinders
2019 Ford Ranger
powertrain — 10R80 transmission hard shifting and jerking
2019 Ford Mustang
powertrain — Head gasket failure—coolant intrusion
2019 Ford Ranger
engine — Water intrusion into spark plug wells
2019 GMC Sierra
engine — Lifter and Valve Train Failure
2019 GMC Yukon
engine — Lifter failure (collapsed/broken oil lifters)
2019 Honda Accord
electrical — Engine stall / loss of power at highway speed
2019 Honda Accord
engine — Blown Head Gasket with Coolant Intrusion
2019 Honda Accord
cruise control — Loss of acceleration and engine performance issues
2019 Honda CR-V
powertrain — Fuel Injector Leakage and Oil Dilution
2019 Honda Fit
engine — Carbon Buildup and Misfires
2019 Hyundai Santa Fe
engine — Excessive Oil Consumption / Burning
2019 Jeep Grand Cherokee
engine — Head Gasket Failure
2019 Kia Optima
engine — Cylinder Misfire / Oil Intrusion into Spark Plugs

Codes are pulled from what owners wrote in their NHTSA filings — they're allegations, not a shop diagnosis. Always confirm with a live scan. Browse all diagnostic codes →

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